affliction

indebtedness that is an affliction;

a crippling affliction of the nervous system.

the affliction of a bereaved family;

Now he was in deep affliction for the loss of his brother.

His deafness is a great affliction to him.

Afflictions are sometimes blessings in disguise.

it was a sad reflection on society that because of his affliction he was picked on.

God hath seen mine affliction and the labour of my hands, and rebuked thee yesternight.

She affected to be spunky about her ailments and afflictions, but she was in fact an utterly self-centered valetudinarian.

O thou chief musician, let us not remain songless because affliction is upon us, but tune thou our lips to the melody of thanksgiving.

For some unlucky people, having a problem with facial recognition is more than just strange. It's an affliction known as prosopagnosia, or face blindness.