lipophilia

the new candidate shows high lipophilia, which explains its rapid accumulation in adipose tissue.

low lipophilia in the formulation limits its ability to cross the blood‑brain barrier.

increasing lipophilia by adding a long alkyl chain improved the membrane permeability of the drug.

the assay measures lipophilia through the partition coefficient between octanol and water.

a moderate lipophilia profile is often desirable for oral drugs to balance absorption and clearance.

scientists correlate the compound's lipophilia with its efficacy in targeting lipid‑rich tumors.

the lipophilia index was used to rank the series of analogues for further development.

during the optimization process, decreasing lipophilia reduced the drug's off‑target binding to plasma proteins.

the intrinsic lipophilia of the molecule determines its passive diffusion across cellular membranes.

high lipophilia can also increase the risk of accumulation in non‑target fatty tissues.

regulatory agencies consider lipophilia as a key parameter when evaluating the safety profile of novel compounds.

the lipophilia measurement was performed using a high‑throughput shake‑flask method.